The suicide rate in Powys over the last three years is the highest in Wales and the fourth highest in England and Wales combined, new figures show.
The figures from the Office for National Statistics show that there were 60 suicides in Powys between 2015 and 2017, at a rate of 16.9 deaths per 100,000 people.
That number has slightly risen compared to the three years from 2012-14.
Across Wales as a whole 12.7 suicides were registered per 100,000 people from 2015-17 - well below the Powys figure.
Mental health charity Samaritans welcomed figures that showed a national decrease in suicides, but said "one death by suicide is still one too many".
Of 5,821 suicides registered last year 4,382 were men, a rate of 15.5 deaths per 100,000 men. However, the male suicide rate was at its lowest level on record in 2017.
Overall, there were 10.1 suicides per 100,000 people in the UK last year.
Samaritans said efforts to reduce stigma around male mental health may have contributed to the reduction, but added that men are still three times more likely to take their own lives than women.
Ruth Sutherland, the charity’s chief executive, said: "It’s encouraging to see the reduction in male suicide.
"We believe that the focus of suicide prevention in recent years to tackle the higher rates in men has contributed to this.
"Added to this, reducing stigma around men’s mental health and encouraging men to open up and ask for help when they are struggling has been beneficial.
"But one death by suicide is still one too many. Suicide is complex and it’s a problem of inequality. It affects the most vulnerable and disadvantaged people in society, male and female, disproportionately.
"This is an urgent public health issue, not simply a health or mental health one."
The statistics include all deaths from intentional self-harm for people over the age of 10 and deaths where the intent was undetermined for those aged over 15 years old.
The news comes ahead of World Suicide Prevention Day on Monday (September 10).
The Samaritans can be contacted on 116 123, or via email at [email protected].